When you want to make a custom page for a particular type of content (like a comic) on a drupal theme you have to make an extra tpl page (page-comic.tpl.php) AND!!! modify the template.php file.
Wish I'd remembered that earlier tonight...
It's always interesting what a CMS does out of the box and what gets filled in with extra modules (i.e., things you add on to the core program). Drupal does a lot of nice things in its core but in general doesn't do everything. In fact there seems to be a healthy ongoing evaluation of what should be in core and what shouldn't.
The Custom pager module for Drupal is what makes it possible to do a webcomic site with Drupal. It's not the whole reason but it's a key piece.
A couple notes for using it -- one if you want the first and last links you're going to have to add a couple lines to the module file and to the CSS file. I think the more "correct" way is to put it in the template file for the theme (instructions here).
I have been tinkering with altertainment.net to be my personal "creative" site (a slight deviation from last year's "about" annoucement) and in doing so - make Drupal webcomic-friendly. Luckily it's almost there so I think with some pushing from me this could actually be a big year for Drupal + Webcomics.
Drupal really missed the boat in not more actively supporting webcomics a few years ago and now Wordpress with the help of the very effective Comicpress theme has taken a huge chunk of that market share. If you're starting from scratch Wordpress + Comicpress is a great way to get going.